WebMay 19, 2015 · BIRC3 is a member of the BIRC family, and apoptosis regulation is one of the important functions of their encoded proteins [19,20]. Furthermore, BIRC2, BIRC3 and TRAF2 had been identified as critical genes in the activation of NF-κB signaling in TNF pathways . At the same time, BIRC3 was observed to be significantly more up-regulated … WebBIRC3 alterations are associated with fludarabine-chemoresistance and adverse prognosis , but few information exist about the response to new therapies . Mutations in key genes of the alternative NF-kB pathway, such as BIRC3 , confer resistance to BTK inhibitors in mantle cell lymphoma (MCL) [ 31 , 32 ], that can be overcome with the addition ...
Exploration of induced sputum BIRC3 levels and clinical …
WebJul 7, 2024 · A change in 3′ UTR isoform expression of the gene encoding the ubiquitin ligase BIRC3 leads to assembly of a protein complex, which changes BIRC3 function in human cells. 3′-seq, 3′-end ... WebJul 9, 2024 · In addition, BIRC3 loss-of-function mutations in del(11q) cells resulted in a higher activation of the non-canonical NF-κB signaling cascade, ultimately leading to … greenleaf flannery o\\u0027connor summary
Set Protein Is Involved in FLT3 Membrane Trafficking
WebMar 22, 2012 · BIRC3, along with TRAF2 and TRAF3, cooperates in the same protein complex that negatively regulates MAP3K14, the central activator of noncanonical NF-κB signaling. 31-34 All inactivating mutations of BIRC3 detected in CLL are predicted to cause the elimination or truncation of the C-terminal RING domain, the E3 ubiquitin ligase … WebFeb 18, 2016 · In this study, we uncover a unique role for BIRC3, as an IAP that is critical in GBM in response to therapy. Using the TCGA dataset of 524 unique samples, we identify BIRC3 is the only IAP... WebMar 14, 2024 · To further explore the function of BIRC3 in pulmonary function, we analyzed the correlation between BIRC3 and pulmonary function. Our results showed … greenleaf flannery o\u0027connor theme