Cyclophosphamide active metabolite
WebAldophosphamide (NSC 254), a putative key metabolite of cyclophosphamide, has now been isolated as a cyanohydrin derivative from an incubation mixture of … WebAldophosphamide (NSC 254), a putative key metabolite of cyclophosphamide, has now been isolated as a cyanohydrin derivative from an incubation mixture of cyclophosphamide with mouse liver microsomes in vitro and from the plasma of a. ... active metabolite phosphoramide mustard, it was expected The cyanohydnin in the ether extract was also ...
Cyclophosphamide active metabolite
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WebMetabolites 2 or 3 or both readily crossed the cell membrane; in contrast, the membrane was relatively impermeable to 4. Intracellular concentrations of 4 could, therefore, be attributed primarily to the intracellular fragmentation of 3. Signals suggestive of either carboxyphosphamide or 4-ketophosphamide were not detected. WebCyclophosphamide is an antineoplastic agent metabolized to active alkylating metabolites with properties similar to those of chlorme-thine. It also possesses marked immunosup …
WebThe active metabolite of leflunomide (A77 1726) inhibits dihydro-orotate dehydrogenase, a mitochondrial enzyme required for the synthesis of pyrimidines. 11 It arrests the … WebAs activity resides exclusively in the metabolites, whose pharmacokinetics are not predicted by those of the parent compound, correlations between cyclophosphamide …
WebCyclophosphamide is a prodrug that requires phase I biotransformation for the activation of the cytotoxic active metabolite being mediated by CYP450 enzyme. ...
WebCyclophosphamide is an inert prodrug converted into 4-hydroxycyclophosphamide (OHCP) by hepatic hydroxylation. OHCP is in equilibrium with its tautomeric aldophosphamide (ALDO). From ALDO, the cytotoxic active metabolites are formed enzymatically by phosphodiesterases; these are the alkylating metab … marzia mensuratiWebSep 30, 2012 · Cyclophosphamide, in which the nitrogen-mustard group (bis-chloroethylamine) is attached to an oxazaphosphorine ring, was introduced as an … marzia miccoliWebApr 14, 2024 · Twelve Asian patients with sarcoma received interval-compressed (ic-) chemotherapy scheduled every 14 days with a regimen of vincristine (2 mg/m2), doxorubicin (75 mg/m2), and cyclophosphamide (1200–2200 mg/m2) (VDC) alternating with a regimen of ifosfamide (9000 mg/m2) and etoposide (500 mg/m2) (IE), with filgrastim … marzia medoneThe active metabolites of cyclophosphamide are highly protein bound and distributed to all tissues, are assumed to cross the placenta and are known to be present in breast milk. It is specifically in the oxazaphosphorine group of medications. See more Cyclophosphamide (CP), also known as cytophosphane among other names, is a medication used as chemotherapy and to suppress the immune system. As chemotherapy it is used to treat lymphoma, multiple myeloma See more Cyclophosphamide is used to treat cancers and autoimmune diseases. It is used to quickly control the disease. Due to its toxicity, it is … See more Adverse drug reactions from cyclophosphamide are related to the cumulative medication dose and include chemotherapy-induced nausea and vomiting See more The main effect of cyclophosphamide is due to its metabolite phosphoramide mustard. This metabolite is only formed in cells that have low … See more Like other alkylating agents, cyclophosphamide is teratogenic and contraindicated in pregnant women (pregnancy category D) except for life-threatening … See more Oral cyclophosphamide is rapidly absorbed and then converted by mixed-function oxidase enzymes (cytochrome P450 system) … See more As reported by O. M. Colvin in his study of the development of cyclophosphamide and its clinical applications, Phosphoramide mustard, one of the principal toxic … See more datatool vs datatagWebApr 11, 2024 · Cyclophosphamide (CTX) is an alkylating agent of nitrogen mustard with broad anti-tumor activity, but excessive or prolonged use can result in toxic s… marzia mediciWebJul 4, 2024 · National Center for Biotechnology Information marzia milanesioWebApr 6, 2024 · Cyclophosphamide 500 mg Powder for Solution for Injection or Infusion Active Ingredient: cyclophosphamide monohydrate Company: Sandoz Limited See contact details ATC code: L01AA01 About Medicine Prescription only medicine Healthcare Professionals (SmPC) This information is for use by healthcare professionals Last … marzia messina