Solifenacin, sold as the brand name Vesicare among others, is a medicine used to treat overactive bladder and neurogenic detrusor overactivity (NDO). It may help with incontinence, urinary frequency, and urinary urgency. Benefits appear similar to other medications in the class. It is taken by mouth. Common side … See more It is used to treat overactive bladder. It may help with incontinence, urinary frequency, and urinary urgency. Benefits appear similar to other antimuscarinics such as oxybutynin, tolterodine, … See more The most common side effects of solifenacin are dry mouth, constipation and urinary tract infection. As all anticholinergics, … See more Mechanism of action Solifenacin is a competitive cholinergic receptor antagonist, selective for the M3 receptor subtype. The binding of acetylcholine to these receptors, particularly M3, plays a critical role in the contraction of See more The compound was studied using animal models by the Yamanouchi Pharmaceutical Co., Ltd. of Tokyo, Japan. It was known as YM905 when under study in the early 2000s. See more Solifenacin is contraindicated for people with urinary retention, gastric retention, uncontrolled or poorly controlled closed-angle glaucoma, severe liver disease (Child-Pugh class … See more Solifenacin is metabolized in the liver by the cytochrome P450 enzyme CYP3A4. When administered concomitantly with drugs that See more Like other anticholinergics, solifenacin is an ester of a carboxylic acid containing (at least) an aromatic ring with an alcohol containing a … See more WebSolifenacin (VESIcare) is used to treat overactive bladder (a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and …

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Web936 rows · Generic Name Solifenacin DrugBank Accession Number DB01591 Background. Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an … WebJun 26, 2024 · Solifenacin oral tablet is a prescription medication that's used to treat symptoms of overactive bladder (OAB) such as urinary urgency, frequent urination, and … how to steam refund a game

Solifenacin succinate 10mg film-coated tablets - medicines

WebJan 4, 2014 · The molecular formula of solifenacin succinate is C 23 H 26 N 2 O 2 with its molecular weight 362.46. Solifenacin is extensively metabolized in the liver. The metabolites observed as one pharmacologically active metabolite (4R-hydroxy solifenacin), and three pharmacologically inactive metabolites (N-glucuronide and the N-oxide and 4R-hydroxy-N … WebDec 1, 2010 · Approved by the US Food and Drug Administration in 2004, solifenacin is a muscarinic receptor antagonist shown in early chemical studies to have significantly greater receptor selectivity for the M3 subtype in the bladder than older drugs such as oxybutynin, tolterodine, and darifenacin [].Approved by the US Food and Drug Administration in 1998, … WebJul 5, 2011 · Solifenacin was disclosed in EP 0 801 067 together with the oxalate salt thereof. Solifenacin is presently being sold as solifenacin succinate (Vesicare®) by Astellas Pharma. Solifenacin succinate was first disclosed in EP 1 714 965 A1, wherein it is also disclosed that the succinate salt results in a purer end product. how to steam potatoes in the microwave